Friday, April 13, 2012

Oxytocin

Heyy guys I know its' too late for a valentines day blog post.. But why need a day to celebrate love?
Lemme tell you about Oxytocin.. The love hormone <3

Oxytocin is secreted by the posterior pitutary.

Physiological roles:
Labour - It contracts the uterus & facilitates birth by a G protein receptor.
Milk ejection reflex - It causes contraction of the myoepithelial cells to let down milk. Remember it isn't responsible for production of milk. Only secretion or ejection more appropriately.
It is also a neurotransmitter (Love is in the air) ;)


It is a peptide that's why it is inactive orally [Destroyed by the acid in the stomach]
It is generally administered by iv or im routes

Uses:
Induction of labour: Either prematurely or in case of postmaturity.
Uterine inertia: When uterine contractions are feeble & labour is not progressing satisfactorily.
Postpartum haemorrhage: Hypertensive patients where ergometrine is contraindicated.
Breast engorgement: Due to inefficient milk ejection reflex. Nasal spray before feeding infant is given.

Do you know Oxytocin and Anti-diuretic hormone ADH  are both octapeptides & have 6 common amino acid residues but differ at position 3 and 8?
Water intoxication because of ADH like action of large doses given along with i.v. fluids can be a fatal complication in renal insufficiency and toxaemia of pregnancy.

Another cool fact: Myoepithelial cells are more sensitive to Oxytocin than the Myometrium

That's all! :)
Happy 13th April ^_^"
-IkaN
(Inspired by Andrea Martins)

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