Saturday, November 23, 2013

Competitive vs Non-Competitive Inhibitors mnemonic

Competitive vs Non-Competitive Inhibitors mnemonic graph
Kompetitive Inhibition: Km Increases; no change in Vmax.

Non-kompetitive inhibition: No Km change, but Vmax decreases.

Usually, on the Lineweaver-Burk Plot, Vmax will represent the Efficacy of a drug on the Y axis & Km will represent the Potency on the X axis.

Mnemonic: "Very efficient & competent"

Of course, that Lineweaver-Burk guy was very efficient & competent! 

The place where I live, there is a tailor's shop named competitive scissors. That's how I remember that competitive inhibitors cross the vectors at the Y axis in Lineweaver-Burk Plot.

Another way to remember this is, competitive inhibitors cross each other competitively, whereas noncompetitive inhibitors do not.

Another mnemonic to remember the shift to left or right in the simple graph is explained in the Oxygen hemoglobin dissociation curve mnemonic.

Hope it helps ^_^

-IkaN

Wanna reblog? Here's the link to the tumblr post!

Credits for "Competitive scissors" mnemonic goes to KhalifaUSMLE

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