Tuesday, February 3, 2015

Study group discussion: Amyloid

Does anyone have awesome things for amylodosis pathology?

Another concept you must understand is that the protein deposits in tissues depending upon where it was derived from.

For example, amyloid from immunoglobulins deposit in tissues of mesodermal origin like kidneys, heart, muscle, tongue.

When it's due to chronic inflammatory disease, it involves parenchymal organs like liver adrenals and pancreas.

Good concept.

Review question! Which amyloid protein is associated with Alzheimers disease?

Beta amyloid

Yes!

And why are patients with downs syndrome more susceptible to early Alzheimers?

Extra chromosome 21 which means extra copy of the presilline gene, I think.

Absolutely right!

Great.

Never knew that!

Oh oh one more!

Which condition is associated with amyloid deposition in the thyroid gland?

Are we talking about the medullary thyroid carcinoma?

Yep. The amyloid deposits are derived from calcitonin in that condition!

Which is the one in patients on dialysis?

Beta micro globulin?
B2 - microglobulin is seen in dialysis associated amyloid.
Derived from the MHC class 1 protein.

Yes. It's because the beta micro globulin is not filtered from the dialysis membrane.

Excellent stuff.

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