Monday, February 23, 2015

Study group discussion: Pathogenesis of symptoms in glucagonoma

Why does glucagonoma cause dermatitis and DVT?

The exact cause isnt known, but one of the reasons may be, because the excess glucagon produced reduces the amount of albumin (which carries Zinc) hence producing a relative deficiency of Zinc. The similar type of which is also found in Zn deficiency. And hence, the dermal manifestation!

The dermal manifestation is called NME - Necrolytic Migratory Erythema

That was one of my MCQ! Also glucagonoma is the commonest type pancreatic tumours to occur in MEN 1 syndrome.

And deep vein thrombosis?

The mechanism for the coagulopathy is poorly understood and seems to be related to an increased factor X production by the pancreatic alpha-cells.

Anyone would like to name the 4 D's of glucagonoma?

Diabetes
Dermatitis (rash),
Deep vein thrombosis (e.g., blood clot in the legs)
Depression

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