Sunday, September 27, 2015

Bleomycin metabolism

This is a short post on pharmacology!

Bleomycin is inactivated by a cytosolic cysteine proteinase enzyme, Bleomycin hydrolase.

This enzyme is widely distributed in normal tissues with the exception of the skin and lungs, both targets of Bleomycin toxicity.

This is why, Bleomycin causes pulmonary fibrosis.

It's also why bleomycin is used in skin cancers like squamous cell cancer.

That's all!

-IkaN

2 comments:

  1. Nice, didn't know that!
    MOC: Bleomycin works by binding to iron --> more free radicals. G2 drug.

    ReplyDelete
    Replies
    1. Thanks for the additional info! :)

      Delete

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