Wednesday, November 30, 2016
Toxic drug levels in inner medulla
Causes chronic tubulointerstitial damage
Results from papillary ischemia due to vasoconstriction of medullary blood vessels (vasa recta)
Phenacetin containing preparations
Polyuria (Due to impaired concentrating ability)
NAGMA (Due to tubular damage)
Hematuria (Due to sloughed necrotic papilla)
Sterile pyuria and WBC casts may also be seen
Ureteric colic, obstruction (Due to sloughed necrotic papilla)
At increased risk of:
Atherosclerotic vascular disease
Urinary tract cancer
Tuesday, November 29, 2016
I am gonna put radial nerve in the simplest form mostly including mnemonics how to learn it's huge muscles supply!
Remember when you were in 1st year and how these nerves used to test your patience?! Let's make it easy.
-Nerve root: C5-T1
-Sensory nerve supply:
Skin of dorsal surface of forearm
Lateral side of the dorsal part of palm
Lateral 3 & 1/2 digits
-Motor nerve supply:
(It supplies extensor compartment)
Here is mnemonic
I: Extensor indices.
D: Extensor Digitorum.
C: Extensor carpi radialis longus.
C: Extensor carpi radialis brevis .
P: Extensor pollicis brevis.
P: Extensor pollicis Longus.
CU: Extensor carpi ulnaries.
ED: Extensor digiti minimi.
So mnemonic is
SID (C)CAP(P) (Read it as cap!) BAT Cu-ed.
Cu = Extensor carpi ulnaris (Supplied by radial nerve not ulnar nerve as it is extensor muscle)
Monday, November 28, 2016
Safia made a mnemonic of TTP and sent it to Medicowesome, hoping it would help someone. So sweet!
Treatment of TTP: CART
In emergency situations, transfuse blood first!
Here is one of the mnemonics which I made to remember types of cranial nerves
"Some say marry money but my brother says beautiful bride matters more!"
S-Sensory ;M-Motor ;B-Both (Mixed)
Sunday, November 27, 2016
Saturday, November 26, 2016
Things that have a mortality benefit in CHF mnemonic: "ABCDES"
A: ACEI and ARBS
B: Beta blockers
CD: implantable Cardiac Defibirillator
Reading material from UpToDate! =)
Here's a quick way to remember the cause of Cleft lip and Cleft palate.
Cleft Lip - failure of fusion of Maxillary and median Nasal prominences!
Cleft Palate - failure of fusion of two Palatine Processes!
Friday, November 25, 2016
Hello guys!!! =D
I am Vinayak, the newest author here.
I would start this mini-autobiography by expressing my gratitude to the coordination of all those zillion coincidences which ended up as me writing for this blog. :)
I have written a few articles for this awesome blog till now but this one took me the most time and brains. It is always challenging to write or say about oneself, it's like being honest without being truthful.
I belong to a very small town in Odisha situated alongside its border with Jharkhand; and like all towns situated at the border, it's pretty backward. I currently live in Mumbai, I first visited this city when I was seven years old to visit my grandfather who was admitted in JJ Hospital, at that time I never would have thought that it would be the same hospital I would become a doctor in many years later. From that moment, it was my dream to live in this city one day, and now everyday I wake up I am happy because I am living my dream! :)
"I believe that imagination is stronger than knowledge, that dreams are more powerful than facts, that hope always tiumphs over experience, that laughter is the only cure for grief and that love is stronger than death." This is my favorite quote. I also believe that "mistakes" should not be frowned upon and berated, that your evolution as a person, as a student, as a family member, as a professional is the result of a "trillion mistakes". One should be so confident about his failures that he is able to fail at the time and place of his own choosing.
As you can gather from the above article, I aspire to be a philosophical writer one day. :D
That'll be all for now! I hope one day I can come back to this article and add another paragraph about living the dream I have right now. :) Thanks IkaN for giving me this oppurtunity!
Wednesday, November 23, 2016
I have with me today a somewhat easy way to remember the Cephalosporins. To rescue you of the Cepha-pocalypse, if you will. Rid you of your Cepha-problems with some Cepha-lutions. (Had to say that. Sorry for the Cephalameness ;;) .)
Remember : ZoLeDrox:
So add cef everywhere now
Remember : ChloroFuro carbons
So CefaChlor And Cefuroxime
(2nd is the least imp generation. So to hell with it. )
So first the Parenteral ones.
Cef (Pronounce Saif like Saif Ali Khan) Opera (like Oprah Winfrey)
Cefti(Like Safety) ke liye
Cefta ke liye not even a
Dime (like the money dime)
And further add Cefti / Cefta to the next two respectively to get :
So that gives you 4 Parenteral drugs. Cefoperazone Cefotaxime Ceftriaxone Ceftazidime.
(Whenever I think of 'Oral' - Denaerys Targaryean comes to my mind. God knows the reason for this Ceph-oral Problems ;;) )
Add Cef related prefixes to each of the 3 words to get your drugs.
Cefdinir Cefixime And Ceftibuten.
Tuesday, November 22, 2016
Monday, November 21, 2016
Glucocorticoids in the fetus are either of maternal origin or syntheiszed from placental progesterone in the fetal adrenal cortex(which lacks zona reticularis). Glucocorticoids are essential for a lot of developmental events, but three of them are most important which goes as follows.
Sunday, November 20, 2016
Here are some important things you should know about erythropoietin therapy.
It is used in patients on dialysis.
Resistance to erythropoietin is most commonly due to iron deficiency.
Adverse effects are associated with rapid rise in hematocrit and hemoglobin - Hypertension, Thrombosis.
Other side effects are: Headache, flu like symptoms, red cell aplasia.
Did you know?
Erythropoietin was the first human hematopoietic growth factor to be isolated.
Erythropoietin was originally purified from urine of patients with severe anemia.
It is banned by the International Olympics Committee.
Let's start with a brief description of Gap Junctions. Take two empty cardboard boxes, assume they are cells. Bore a hole in each one of them and then enter a small straw in it. Then arrange the two boxes(cells) in such a way that the two straws are aligned perfectly with each other and that their cavities form a continuous column, so that if you pour water in one box it should completely go into the other one without even a single drop falling in between them.
Saturday, November 19, 2016
Hello lovely medical students!
Priapism is persistent, painful erection that develops without sexual simulation.
Here are a few causes of priapism:
(Mnemonic: PRazosin causes PRiapism)
(Mnemonic: Trazodone causes a boner - TrazoBone)
Perineal or genital trauma
Sickle cell disease and leukemia
Always check medications first, since it is often drug induced.
Friday, November 18, 2016
Hello! In this post, I'll be talking about nephrotoxic antimicrobials.
Let's start with Aminoglycosides!
Aminoglycoside toxicity manifests in the form of tubular necrosis.
Did you know AKI due to Aminoglycosides manifest 5-7 days after therapy even after the drug has been discontinued? :O
Aminoglycosides accumulate in the renal cortex and cause non oliguric AKI. Hypomagnesemia is a common finding.
Amphotericin B also causes tubular necrosis. It binds to tubular membrane cholesterol and introduces pores. Clinical findings include polyuria, hypomagnesemia, hypocalcemia and NAGMA.
Mnemonic for nephrotoxic drugs: Drugs with A!
Antivirals like acyclovir, tenofovir, cidofovir, foscarnet, pentamidine.
(Cause tubular toxicity)
Antibiotics like penicillin, cephalosporins, quinolones, sulfonamides, rifampin.
(Cause acute interstitial nephritis)
Remember, in acute interstitial nephritis, WBCs, WBC casts and urine eosinophils will be seen. However, in AKI, the urine sediment will show granular casts.
The predominant feeling I have is that if gratitude (=
Thursday, November 17, 2016
Currently, the best understood of the primary generalized seizures is the Absence Seizure(also called Petit Mal seizure).
To understand the pathophysiology of absence seizures, we first have to be acquainted with the physiology of slow-wave(Stage 3) sleep; since they both have similar EEG reading patterns; i.e., the 3-per-second spike-and-wave activity.
In the awake state, the thalamocortical circuits are in "transmission" mode, whereby incoming sensory informations are faithfully transmitted to the cerebral cortex. Whereas in slow-wave sleep, these circuits are in"burst" mode, because of the bursting activity of a unqiue, dendritic T-type Calcium channel in the thalamus which alters the incoming sensory signals in such a way that the output signals to the cortex have an oscillatory firing rate; but no sensory information is transmitted to the cortex. Something similar happens in Absence Seizure.
In absence seizure, there is abnormal, abrupt activation of this T-type calcium channel in the awake state. This has been postulated to be due to hyperpolarizaion of relay cells in thalamus which in turn is due to increased GABAergic input from the reticular nuclei.
Tuesday, November 15, 2016
Good morning! =)
I was studying about radiolucent kidney stones and thought of sharing what I learnt with you all.
Mnemonic for radiolucent renal calculi: CATIX URL
Another mnemonic for medication stones: GUEST MIC
Guaifenesin stones (Radiolucent)
Ephedrine stones (Radiolucent)
Sulphonamides stones (Radiolucent)
Triamterene stones (Poorly radiopaque)
Magnesium trisilicate stones (Poorly radiopaque)
Indinavir stones (Radiolucent)
Cephalosporins stones (Radiolucent)
If you are asked to choose the radiolucent one between Orotic acid stones and cysteine stones, choose orotic acid. It is radiolucent, cystine is poorly radioopaque.
Magnesium ammonia phosphate (struvite) and Cystine calculi are less radiodense and are more difficult to visualize. Uric acid, orotic acid, xanthine, triamterene, dihydroxyadenine, and indinavir calculi are radiolucent and might not be seen on a plain radiograph.
Predisposing factors for uric acid stones:
1. Low urinary pH
2. High uric acid excretion
Treatment for uric acid stones:
1. Alkalinization of urine
(Sodium bicarbonate, potassium citrate)
2. Increase fruits, veggies. Decrease animal flesh.
3. XOI - Allopurinol, Febuxostat
Alkalinization of urine mnemonic: ABC.
Alkalinization. Bicarbonate. Citrate.
(Sodium bicarbonate and potassium citrate are used for alkalinization of urine)
Monday, November 14, 2016
We were discussing a MCQ from pathologystudent.
Here's the question:
On a routine physical examination of an elderly male patient with no other medical problems, you note that his earlobes and fingertips are pale and slightly bluish. A CBC shows a hemoglobin of 10.6 g/dL (12 – 16) and an MCV of 88 (80 -100). Numerous red blood cell agglutinates are seen on the blood smear, made by smart technologists in your laboratory. Which of the following statements is true?
1. The antibody bound to the patient’s red blood cells in this disorder is probably IgG
2. Complement is probably bound to the patient’s red cells
3. The spleen is the main site of red cell destruction in this patient
4. 1 and 3
5. 1, 2, and 3
1 is not true. It's cold agglutinin disease. The main antibody is IgM here.
2 is correct since complement is involved.
The main site of destruction is liver macrophages (Kupffer cells). Therefore, 3 is incorrect.
Is there a specific reason for it?
Liver RECs have loads of C3 specific receptors. So most extravascular hemolysis that occurs in cold agglutinin disease is in the liver.
Another common mechanism of hemolysis in cold agglutinin disease is direct complement mediated intravascular hemolysis.
There's C3b on RBC and macrophage has CR3 (Complement receptor 3).
Liver macrophages lack the capacity of spleen to sequester cells. Hence, here the RBC destruction in liver occurs by phagocytosis predominantly.
Thanks, Divya, for explaining this.
Sunday, November 13, 2016
For those who don't know -
Tourette syndrome is a disorder involving multiple motor and vocal tics, for at least a year, before 18 years of age.
Mnemonic: T for Tourette, T for Tics!
Tourette syndrome is associated with ADHD and OCD.
Tourette - ADHD, OCD.
Treatment - Antipsychotics like tetrabenazine, risperidone, fluphenazine are preferred.
Clonidine and Clonazepam maybe useful.
Friday, November 11, 2016
Chronic lymphocytic leukemia is proliferation of normal B lymphocytes that function abnormally.
The WBC count in CLL is > 20,000/flL with 80-98% lymphocytes.
Smudge cells are seen in CLL.
Staging of CLL mnemonic
High LSAT score :D
Stage 0: High WBC
Stage 1: Lymphadenopathy
Stage 2: Splenomegaly + Hepatomegaly
Stage 3: Anemia
Stage 4: Thrombocytopenia
For stage 0 and stage 1, no treatment is required.
Therapy is indicated for patients with advanced stage disease, high tumor burden, severe disease-related "B" symptoms, or repeated infections.
Hepatosplenomegaly, anemia and thrombocytopenia are preferably treated with fludarabine and rituximab (FR).
For refractory cases, cyclophosphamide can be used (FCR regimen)
Older individuals (> 65 years of age) can be treated with ibrutinib, a bruton’s tyrosine kinase (BTK) inhibitor (preferred) or chlorambucil plus anti-CD20 monoclonal antibodies.
Autoimmune hemolysis or thrombocytopenia is treated with prednisone (Autoimmune warm IgG antibodies)
CLL has a good prognosis compared to other leukemias. Most common cause of death is due to infection.
Tuesday, November 8, 2016
Hello! This is a mini post on bulbar and pseudobulbar palsy.
Bulbar palsy is the paralysis of the muscles supplied by the cranial nerves coming out from the bulb also known as the medulla (Cranial nerves 9, 10, 12) and it is lower motor neuron palsy.
Pseudobulbar palsy is paralysis of the same cranial nerves but the upper motor neuron type. Mostly due to lesions in the brain.
Mnemonic: pseUdo has a U for UMN lesion.
Monday, November 7, 2016
Hemoglobin concentration of 4.0 g/dL
Total white cell count of 25000/cmm
Platelet count of 60000/cmm
Monoclonal gammopathy (M spike) was seen in gamma globulin region, which turned out to be IgM on immunofixation.
Fundus examination revealed venous dilatation, tortuosity and superficial retinal hemorrhages.
Saturday, November 5, 2016
Friday, November 4, 2016
If you can't remember the drugs used in the CHOP regimen of Non-hodgkin's lymhoma, I have a mnemonic for you.
Thursday, November 3, 2016
If you can't remember the drugs used in the ABVD regimen of Hodgkin's lymhoma, I have a mnemonic for you.
What is ADP (Adenosine diphosphate) fibrinogen test?
ADP, formed by Ib receptor, acts on IIb IIIa receptor through fibrinogen and causes aggregation.
In vWD and Bernard Soulier disease (Ib defect), if you add ADP, aggregation would take place and test will be normal as it acts on IIb IIIa receptor.
In glanzmann thrombasthenia, the IIb IIIa receptor is deficient. ADP can not act on the receptor, if added. That's why, the test becomes abnormal.
Therefore, the test is normal in vWD, Bernard soulier disease and abnormal in glanzmann thrombasthenia.
Explained by Abhishek Shukla
Wednesday, November 2, 2016
Evolves over one to three days.
Sluggish neuromuscular responses (Rigidity, bradyreflexia)
Typical course: Mental status changes appear first, followed by rigidity, then hyperthermia, and autonomic dysfunction (Tachycardia, high BP, tachypnea)