1. Vareniciline increases the risk of suicide and depression. T or F
2. Vareniciline increases the risk of CVS events. T or F
ANSWERS
1. False
Despite earlier concerns, subsequent data indicate that varenicline does not cause an excess of neuropsychiatric side effects compared with nicotine replacement or bupropion. In December 2016, the US Food and Drug Administration (FDA) removed the boxed warning about potential neuropsychiatric side effects that they had required in 2009
2. False
Although concern has been raised that varenicline might increase the risk of adverse cardiovascular events, the bulk of the evidence does not indicate an increased risk. Overall, for patients at low risk for an acute coronary event, it appears unlikely that varenicline is associated with a clinically meaningful increase in cardiovascular events. For high-risk patients, the effect of varenicline on cardiovascular event occurrence is less certain.
Reference: Uptodate and Uworld
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