Monday, February 18, 2019

Zoledronic Acid

Use

Bone metastases from solid tumors (Zometa): Treatment of documented bone metastases from solid tumors (in conjunction with standard antineoplastic therapy); prostate cancer should have progressed following treatment with at least one hormonal therapy.

Glucocorticoid-induced osteoporosis (Reclast, Aclasta [Canadian product]): Treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are initiating or continuing systemic glucocorticoids in a daily dose equivalent to 7.5 mg or more of prednisone and who are expected to remain on glucocorticoids for at least 12 months.

Hypercalcemia of malignancy (Zometa): Treatment of hypercalcemia (albumin-corrected serum calcium ≥12 mg/dL) of malignancy.

Limitations of use: Safety and efficacy for treatment of hypercalcemia associated with hyperparathyroidism or with other non-tumor-related conditions have not been established.

Multiple myeloma (Zometa): Treatment of osteolytic lesions of multiple myeloma.

Osteoporosis in men (Reclast, Aclasta [Canadian product]): To increase bone mass in men with osteoporosis.

Osteoporosis in postmenopausal women (Reclast, Aclasta [Canadian product]): Treatment and prevention of osteoporosis in postmenopausal women.

Paget disease of bone (Reclast, Aclasta [Canadian product]): Treatment of Paget disease of bone in men and women. Note: In patients without contraindications, zoledronic acid is recommended as the treatment of choice per Endocrine Society guidelines (Singer 2014).

Mechanism of Action :

A bisphosphonate which inhibits bone resorption via actions on osteoclasts or on osteoclast precursors; inhibits osteoclastic activity and skeletal calcium release induced by tumors. Decreases serum calcium and phosphorus, and increases their elimination. In osteoporosis, zoledronic acid inhibits osteoclast-mediated resorption, therefore reducing bone turnover.

100% Bioavailability

Compared to oral bisphosphonates, which have only 0.3-0.4 % of bioavailability.

Bhopalwala. H

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