Hormones are divided into 2 groups
Group 1 hormones- Act via nuclear receptors
Type 1- Have cytoplasmic receptors with effector elements in the nucleus e.g Steroid hormones (cortisol), Gonadal hormones (Androgens, estrogens, progesterones)
Mnenonic- There is only 1 General Secretary
Type 2 -Directly act at the nucleus e,g, vit D,vit A, Thyroxine
Mnemonic-Directly AcT at the nucleus
Group 2 hormones- Act via the cell membrane surface receptors
1. GPCR- Very extensive, will require a second post
2.Tyrosine Kinase- All Growth factors(Except TGF alpha and beta) and Insulin (Tip to remember: TKI or tyrosine kinase inhibitors are used in a lot of malignancies, there's abnormal growth in malignancies and hence TKIs stop that growth, also I in TKI will remind you of insulin, Insulin causes fat to grow!!)
3. JAK-STAT(cytokine receptor) Mr. JAcK is a Drunkard!! all he needs is PEG
Prolactin,
Erythropoietin,
Growth hormone.
(Pro tip: GH and PRL are called as twin hormones, JAK STAT mutations are involved in Myeloproliferative disorders say Polycyathemia and erythropietin is needed there)
4.Serine threonine Pathway: This pathway is a perfect BAIT for the hormones.
Bone morphogenic protein
Activin
Inhibin
Trasformation growth factor alpha and beta
That's all for today!
Have fun and stay safe!
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Dr. ShilPill
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