This is a short post on pharmacology!
Bleomycin is inactivated by a cytosolic cysteine proteinase enzyme, Bleomycin hydrolase.
This enzyme is widely distributed in normal tissues with the exception of the skin and lungs, both targets of Bleomycin toxicity.
This is why, Bleomycin causes pulmonary fibrosis.
It's also why bleomycin is used in skin cancers like squamous cell cancer.
That's all!
-IkaN
Nice, didn't know that!
ReplyDeleteMOC: Bleomycin works by binding to iron --> more free radicals. G2 drug.
Thanks for the additional info! :)
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