Hello
DRESS syndrome and Dressler's syndrome - what's in the name?
DRESS syndrome - an acronym
Drug Rash with Eosinophilia and Systemic Symptoms
- delayed type IV-b hypersensitivity reaction (immune-mediated)
- occurs up to 2-6 weeks after starting the offending agent/drug(s)
- fever >38 C, morbilliform rash, lymphadenopathy (at least two sites), multi-organ involvement
- eosinophils >700 uL, atypical lymphocytes
- raised ALT
- offending drugs: penicillins, vancomycin, carbamazepine, phenytoin, rifampin, isoniazid, nitrofurantoin, sulfa drugs, omeprazole, captopril, allopurinol (Differential diagnosis: Stevens- Johnson syndrome )
- more prevalence in patients with renal and liver dysfunction and with use of diuretics (source)
- may be associated with reactivation of HHV-6
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Dressler's syndrome - named after a cardiologist William Dressler, 1956
- post-cardiac injury syndrome
- auto-immune mediated pericarditis
- up to 2-8 weeks after severe/transmural MI
- patient may have a h/o viral/fibrinous pericarditis or other antiviral infections.
- a young patient with B-negative blood group (source)
- may be a h/o use of halothane anesthesia
- triad of pleuritic chest pain, pericarditis, and pneumonitis with low-grade fever.
That's all
- Jaskunwar Singh
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