Sunday, August 2, 2020
Breastfeeding: Good Vs Poor Latch
Technique of Breastfeeding
Thursday, April 16, 2020
Thioamides in pregnancy
Propylthiouracil is a pro. It always comes first (used in first trimester of pregnancy).
Methimazole causes Malformations in the embryo (teratogenic).
There are two M's in MethiMazole. This drug is used in second (and third trimester of pregnancy).
Propylthiouracil piles up, causing liver toxicity, thus limiting its use.
Hope it helps
- Jaskunwar Singh
Wednesday, April 15, 2020
Importance of Ischial spine
Friday, April 3, 2020
COVID-19 and Pregnancy: Should Mothers Be Concerned?
WHO’s official stand is that there is no higher risk in pregnancy of severe illness BUT because there are trials underway and due to the bodily changes in pregnancy, one can not know the extent of COVID-19 in these patients. [1] Due to the evolving crisis, we are seeing newer studies every day with new results. A study conducted in early February on 38 pregnant women showed that it did not lead to maternal deaths, and neither were there any confirmed cases of intrauterine transmissions, with rt-PCR being negative in all the neonatal specimens tested, hence leading to the belief that there is no intrauterine or transplacental transmission. [2] Even the CT scans done on pregnant women with COVID-19 positive samples, did not show major changes and recovered from pneumonia adequately. [3]
Sunday, February 23, 2020
Schroeder's Vs Bandl's ring
Friday, February 21, 2020
Post Partum Hemorrhage - Updates
Following bleeding scenarios amount to PPH under the latest WHO document
- Blood loss >500 mL in c/o Vaginal delivery
- Blood loss > 1 L in c/o C Section + in c/o twins
- Blood loss > 1.5 L in c/o Hysterectomy
- Blood loss on any case more than what is expected over a period of 24 hours
Following bleeding scenarios amount to PPH as per the latest ACOG recommendations
- Blood loss equal to or more than 1 L irrespective of mode of delivery
- Bleeding with signs and symptoms of hypovolemia
Updates in Management of PPH
- Uterine massage is added along with uterotonics
- PGE1 if given Per Rectally (not recommended), 1000 micrograms is advised
- Inj Tranexamic Acid is recommended in all bleeding diasthesis - 1 gram slow IV (over 20 minutes)
- Mechanical Devices allowed
- Sengstaken Blakemore Catheter
- Bakri Balloon Catheter
Saturday, December 28, 2019
Sonographic diagnostic features of monochorionic monoamniotic twin pregnancy
Monday, November 25, 2019
Risk factors for puerperal sepsis mnemonic
Risk factors for puerperal sepsis mnemonic:
PUERPERAL SEPSIS
Maternal complications of diabetes in pregnancy mnemonic
Maternal complications of Diabetes in pregnancy mnemonic:
PREGNANCy
Saturday, November 2, 2019
Tuesday, July 30, 2019
Kleihauer–Betke test
Kleihauer–Betke test: KB test.
1) Why do we do this test?
- To calculate Fetal RBCs in blood. This helps us to measure amount of Anti-D required to neutralize it.
2) How do we do it?
- Basically, we are going to take blood sample and add acid to it and measure red blood cells under microscope.
3) How do you differentiate Fetal and Maternal blood?
- Fetal RBCs are acid resistant. Adding acid in the preparation leads to lysis of the Maternal RBCs.
4) What are important points regarding this test that should be kept in mind while solving MCQs?
- Do not confuse it with APT test. APT is done in Alkali and it is a Qualitative test. It helps in differentiating Maternal and Fetal blood only. On the other hand, in KB test (Also know as Acid dilution test), we use Acid and we quantify Fetal blood.
- Minimum dose even after KB test is 300 microgram.
5) How do we calculate amount of Anti-D required to neutralize Fetal RBCs?
- If 20 RBCs in HPF are seen, then it means 1 ml Fetal blood is in circulation.
-1 ml fetal blood requires 10 microgram of Anti-D for neutralization
6) What if they don't mention "Fetal RBCs" and instead, mention "Fetal blood" in the question?
- Here is a trick. Always remember, 1 ml Fetal blood has 0.5 ml Fetal RBCs.
Applied calculations:
Q1) A Multigravida with twin pregnancy has 20 ml Fetal RBCs. How much Anti-D will be required to neutralize it?
(Take a deep breath. You don't need to worry about twin pregnancy. All the important points are already covered in above segment)
- 20 ml Fetal RBCs = 40 ml Fetal blood.
- 1 ml Fetal blood = 10 micrograms Anti-D
Answer = 400 micrograms Anti-D
400 micrograms is the enough amount of blood given to neutralize 40 ml fetal blood or 20 ml Fetal RBCs.
(Done easily? Perfect ! Let's level up.
I want you to go through blog once again before heading down.)
Q2) This time patient comes with same clinical presentation but with 20 ml fetal blood.
- 1 ml fetal blood = 10 micrograms of the Anti-D
- 20 ml Fetal blood will require 200 micrograms Anti-D.
Perfect. We calculated correctly but my question is - Will you administer 200 micrograms Anti-D to the patient showing 20 ml Fetal blood to neutralize it?
Answer is big 'NO'.
Go back to bullet (4) point 2:
Minimum amount is still 300 micrograms after KB test. So you cannot administer 200 micrograms. You have to give 300 micrograms.
I hope this blog is better than my previous blogs. Any important points you have regarding KB test, do comment in comment box
That's it
-Demotional bloke
Thursday, July 25, 2019
Monday, April 29, 2019
Cardiovascular changes in pregnancy
At term
- Blood volume increases by 50%
- increased uterine blood flow 500-800ml/min
- uterus recieves 10-15% cardiac output
Saturday, April 27, 2019
Massive blood transfusion strategy
In patients with massive haemorhage with a loss of more than 40% of blood volume - rapid transfusions are given with colloids, crystalloids and packed RBCs.
This causes coagulopathy by diluting the a clotting factors.
Hence, prophylactic infusion of platelets and fresh frozen plasma is done.
Initially, it was given in a ratio of 1:1:4
One part platelet & ffp transfusion to every 4 bags of blood.
It has been renewed now to 1:1:1 ratio
It has caused significant reduction in mortality 40% versus 60%
Thank you!
40% blood loss translates to grade 4 hemorrhagic shock or grade 1 degree of urgency per the urgency grid for obstetric hemorrhage. I removed the grading in the initial part of the post to avoid confusion as different grades mean different severity of shock based on the scale used.
- sakkan
Sunday, March 10, 2019
LMR (Last minute revision) Stuff for obstetrics and gynecology drugs
In LMR sessions, I will share final year MBBS Viva things on drugs and specimen.You can add your list in the comments below.
Today I will share the Obstetric and gynaecology viva on drugs.
Lets get started.
1.Tranexamic acid and mefanemic acid combination
Tranexamic acid:
- anti-fibrinolytic
- Amino caproic acid derivative
- CONVERTS plasmin to plasminogen
- given during menstruation
- Adverse effect:- Intracranial thrombosis
Mefanemic Acid:
- COX inhibitor.
- Given during menstruation
- Adverse effect:- dyspepsia,gastric ulcer
- Ovulatory cycles of DUB
- Post IUCD bleeding
- Post sterilization mennorhagia
- Fibroid
Doxylamine is anti histaminics that has effects on acetylcholine and serotonin release. And you know their receptor is present on CTZ centers.
Vitamin B6 is pyridoxine.
In pregnancy and poor diet the amount decreases.
USE:- Emesis during pregnancy at bedtime (not more than 2 tablet in a day).
3.Dinoprostone gel
- Prostaglandin E2
- 500 micro gram into the cervical canal below the level of internal os
- Or 1-2 mg in the posterior fornix
- maximum 3 doses 6 hourly
- Applied in posterior fornix when membrane is ruptured
- applied in internal os when membrane is intact
- USE- Cervical ripening in IOL.
- Before and after CTG monitoring is must.
- C/I- Previous CS, Impending scar rupture,fetal distress,asthma,severe heart disease
4.L-Arginine+Folic acid+isothiocyanidin
- L-Arginine is precursor for Nitric oxide generation that will lead to vasodialtion
- USE: In IUGR, Severe oligohydroamnios, preventing pre-eclampsia
- PGE1
- ROUTE= sublingual,vaginal,rectal (never parentral)
- S/E:Fever,chills,shivering
- Teratogenic: Mobius syndrome (Category X drug)
- USES:-
- OBSTETRIC USES:
- Termination of pregnancy
- PPH prevention and treatment.
- Pe hysterectomy
- IUI
- Cervical pregnancy
- Treatment of peptic ulcer caused by NSAIDs.
- Loop diuretic.
- prior to blood transfusion in severe anemia
- congestive cardiac failure
- used in complications not as anti hypertensives
- PIH with massive edema
- USE: Mixed bacterial and fungal vaginosis
- USE: GERD, peptic ulcer
- Injectable Anti-coagulant
- In 1st trimester
- Antidote: Protamine sulfate
- USE: DVT, APLA, PE, recurrent abortion (Prophylaxis:ASPIRIN+HEPARIN)
- Prophylactic: 100mg elemental iron+500 micro gram folic acid daily from 2nd trimester throughout pregnancy +6 month postpartum
- Treatment: Oral iron 200 mg elemental iron daily
- Folic acid deficiency lead to abortions, abruptio, IUGR, NTD
- In folic acid deficiency dose is 4000mg
- IgG, intramuscular
- 300 micro gram=15 ml of D positive red cell/ 30 ml of fetal whole blood
- If ICT -VE at 28 weeks
- 2 doses 12 mg betamethasone i/m 24 hours apart
- 4 doses 6 mg dexamethasone 12 hours apart
- IV for Heart resuscitation, poor kidney function, Cocaine toxicity
- Poisoning cases
- Reviving newborn
- Preventing chemotherapy side effects
- Hyperkalemia
- metabolic acidosis
- Central Muscle relaxant and anti convulsant, Tranquilizer
- S/E:- Maternal (Hypotension) and Fetal (Respiratory depression, hypotonia)
- Direct arteriolar vasodilator
- Calcium channel blocker
- USE:Tocolytics
- A/E: Flushing, Hypotension, headache, Inhibition of labor
- Anti-hypertensive
- combined alpha and beta blocker
- orally 100mg tid to 2.4 g daily
- USE: Hypertension and hypertensive crisis
- S/E:tremor, headache, CCF.
- C/I: Hepatic disorder, asthma, CCF
- Anti-spasmodic (PDE-4 Inhibitor)
- Enhance cervical dilatation during childbirth
- USE: Acute renal colicky, augment labor.
Monday, November 5, 2018
Anti-Ro/SSA antibodies and neonatal lupus
Did you know? Anti-Ro/SSA antibodies are associated with neonatal lupus (congenital heart block (CHB), neonatal transient skin rash, hematological and hepatic abnormalities).
How do I remember this?
Saturday, September 22, 2018
Congenital syphilis picmonic
With reference to this post: http://www.medicowesome.com/2017/03/buzz-words-for-congenital-syphilis.html
Friday, March 30, 2018
Age of Gestation and Estimated Date of Delivery (EDD)
This is a nice video explanation by Jay!
Tuesday, March 6, 2018
Nonstress test and biophysical profile mnemonic video
Video notes, Nonstress test and biophysical profile mnemonic: http://www.medicowesome.com/2018/03/nonstress-test-and-biophysical-profile.html
Biophysical profile mnemonic and step 2 CK notes: http://www.medicowesome.com/2016/09/biophysical-profile-mnemonic-and-step-2.html
-IkaN