Friday, August 2, 2013

Difference between iron deficiency anemia and anemia of chronic disease

Hi everyone!
Sometimes simply reading doesn't help you get the difference..
So I made these notes to help you have a visual idea of the terms used while describing these diseases.

Difference between iron deficiency anemia and anemia of chronic disease
Serum ferritin is a soluble iron binding storage protein.

It’ll help you distinguish between anaemia of chronic disease (ACD) and iron deficiency anaemia (IDA). Both are microcytic!

In iron deficiency, your iron stores are decreased.
So, obviously, serum ferritin will be decreased.

In anaemia of chronic disease, liver synthesizes hepcidin.
Hepcidin is a key that locks up iron in the bone marrow and prevents it’s release to transferrin.
That’s why, ferritin is increased. (Stores are there, but unavailable!)

What is hepcidin?
It is an antimicrobial peptide secreted by the liver in response to inflammation (Acute phase reactant).
Antimicrobial? @_@
Yes, the body thinks decreasing availability of iron to microorganisms will kill em!

Note: Ferritin and transferrin are inversely related
Decreased ferritin stores increases synthesis of transferrin from the liver and vice versa.
Therefore, in iron deficiency anaemia, you’ll have an decreased ferritin and increased TIBC.
And in anaemia of chronic disease, you’ll have a increased ferritin and decreased TIBC.

PS: In IDA, the ferritin is low (Unless the patient has some other condition that makes ferritin go up – like systemic inflammation or something!)
If the ferritin is low, be sure it’s IDA.
If it’s normal or high, it could be either IDA (with some other condition going on as well) or ACD.

That's all!

-IkaN

12 comments:

  1. Please note it's wrongly typed....
    In ida there is decreased ferritin and increasef tibc.

    ReplyDelete
    Replies
    1. Typing mistake ^__^"
      Thank you for the correction!

      Delete
  2. Replies
    1. Rapid Review Pathology, 4th Edition by Edward Goljan.

      Delete
  3. Really a good account...
    thanks

    ReplyDelete
  4. Can i know why is it in ACD, there is decrease in TIBC. Is TIBC related to ferritin?

    ReplyDelete
    Replies
    1. TIBC is related to transferrin. The stuff that carries iron in blood.

      In ACD, the body doesn't want to transport iron.. It locks up iron so that it is unavailable to microorganisms.

      So even though ferritin (storage iron) is increased, transferrin is decreased during inflammation.

      Delete
  5. Simple & precise explanation !
    Too good :)

    ReplyDelete
  6. so simple! Thanks! One question, what is the importantce of iron to microorganisms that deprivation will kill them?

    ReplyDelete
    Replies
    1. This should help! http://www.medicowesome.com/2015/02/of-iron-bacteria-and-hemochromatosis.html

      Delete

This is express yourself space. Where you type create something beautiful! <3
Wondering what do I write? Well..
Tell us something you know better. You are a brilliant mind. Yes, you are! ^__^
Ask about something you don't understand @_@?
Compliment... Say something nice! =D
Be a good critic and correct us if something went wrong :|
Go ahead. Comment all you like here! (:

Related Posts Plugin for WordPress, Blogger...