Tuesday, February 18, 2014

Collagen in wound healing & Ehlers-Danlos syndrome mnemonic

Hey guys!

We all know that the tensile strength of wound increases after 3 months after a type of collagen is replaced by another collagen.. But which one?
I remember the quote, "United we stand, divided we fall."
So first, type III collagen is laid. Then you unite the I's to make type I collagen :)

Random fact: Metalloproteinases (collagenases) replace type 3 collagen by type 1 collagen. This increases the tensile strength by upto 80%.

Since we are talking about collagen, let's talk about Ehlers-Danlos syndrome. It is characterized by defects in type I and type III collagen.
Remember "EDCBA"
Ehlers-Danlos, Collagen, Bowel rupture and Bleeding into skin, Aortic dissection.
Hypermobile joints, hyperelasticity of skin and poor wound healing are also seen in Ehlers-Danlos syndrome.

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