Wednesday, February 18, 2015

Study group discussion: Fluoroquinolones

Review questions please!

You are asking questions?

No, I was waiting from them! :)

Haha review questions then!

Which enzyme does fluoroquinolones inhibit in gram negative and gram positive bacteria?

DNA gyrase!

Umm specific types of it in both gram negative and gram positive bacteria.

Topoisomerase 2 in gram negative and topoisomerase 4 in gram positive.

What are the side effects of quinolones?

Tendon rupture, photo toxicity!

Can cause convulsion.. Because they are also GABA inhibitory.

Somnolence. You don't prescribe them to people who drive for the same reason.

QT prolongation.

Nausea, vomiting and taste disturbance.

Tendon rupture in elderly people taking steroids.

QT prolongation only in gemifloxacin, lomefloxacin, moxifloxacin and levofloxacin.

Why don't you give it in pregnant ladies and young children?

In children, it can cause some defects in bone/cartilage formation. So it'll cause bending of long bones and stuff.

Yup. It causes defect in collagen.. Articular rupture and tendonitis!

Okie moving on.. Name the respiratory fluoroquinolones.

There are four of them. They have been termed that because they can be given to patients suffering from COPD.

Gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin.

Could you explain the concept of respiratory fluoroquinolones a lil bit more? It's a new concept to me.  sorry! Why can't you give the others to someone with COPD?

They are especially used for lower RTI and upper RTI.. Cause they inhibit anaerobic, gram positive, atypical as well as gram negative aerobes. The others do that too..but these are especially preferred for respiratory infections.

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