Wednesday, June 15, 2016

Vitamin D in Type - 2 Diabetes Mellitus

Hey awesomites!

Vitamin  D has an important role in overcoming insulin resistance in type 2 diabetes. Here's how...
To understand this, let's talk about one of our specialised immune cells, the macrophages!
When fat cells accumulate in excess, as happens in diabetes, the macrophages move in and engulf these cells.
This results in inflammation which is more so in fat/obese individuals.
Macrophages also produce 'cytokines', which are responsible for decreased insulin action in liver and muscles. So higher cytokines means more insulin resistance!

Macrophages have vitamin D receptors on their cell surface. So, VitaminD deficiency leads to increased macrophage activation - more cytokines production- more Insulin resistance - type 2 diabetes!

Note:- Vitamin D is given as supplement with Quietiapine (atypical antipsychotic) to prevent onset of diabetes due to this drug!

That's all!

-Jaskunwar Singh

Related post: Migraines linked to vitamin D deficiency

4 comments:

  1. Replies
    1. Yep I was searching for this for long.. thanks ikan :D

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    2. Recently had a vitamin D deficiency l was 15ng/100ml, was put on Colcalciferol for 6 weeks and my diabetes type 2 numbers have been terrific so clearly there is some correlation with this news.Thanks.L.M

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    3. That's great Les... I hope the levels have improved now and its under control.. would love to hear from you.. Woohoooo!! :D

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