Saturday, September 9, 2017

Cytochrome P450 3A4



Hello everyone!

Today lets discuss the Cytochrome P450 3A4
It is the microsomal enzyme involved in metabolism of xenobiotics. Maximum number of drugs are metabolised by CYP 3A4 in our body.

Here’s how you  remember the substrates and the inducers of the enzyme:

“In emergency Straightaway give a CPR and ACT SaNely

The inducers are:
S: St John Wort
CPR: Carbamazepine, Phenytoin, Phenobarbitone, Rifampicin


The substrates are:
ACT SaNely

A-Amiodarone
A-ACT drugs(Anti Histamines) 
*A-Astemizole
 *C-Cisapride
*T-Terfenadine
C- Cyclosporine
T- Tacrolimus
S- Statins
N-Navirs (protease inhibitors)




And how do we remember the inhibitors?

Shout “Fire in the Hole!”
Fluconazole   Ketoconazole
and Ritonavir and Erythromycin
Also you can have some grapefruit juice to chill out! Grapefruit juice is also a Inhibitor of CYP3A4.

That’s all
Thank you,
Chaitanya Inge

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