Monday, October 1, 2012

Mechanism of action of antibiotics (Protein synthesis inhibitors) mnemonic

A protein synthesis inhibitor is a substance that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.

How do you remember them?

A is the 1st letter, thus Aminoglycosides inhibit Initiation (the first step of translation).
Prevents formation of the initiation complex.

Tetracyclines (TTC):
tRNA Tries but can’t.
Prevents the aminoacyl-tRNA from attaching to the A site of the ribosome.

The only one with a “P”, thus the only one inhibiting Peptide bond formation (by peptidyltransferase).

Prevent the Movement of ribosomes.
Prevents translocation.

Makes ribosomes Cling to mRNA.
Prevents translocation.

Like erythromycin.
Prevents translocation.

Like an aminoglycoside
Prevents initiation.

For those you can't remember which subunit -
"buy AT 30, CELL at 50"
A = Aminoglycosides
T = Tetracyclines
30 = 30S

C = Chloramphenicol,
E = Erythromycin (macrolides)
L = Linezolid
L = cLindamyin
50 = 50S

Note: Aminoglycosides also attach to the 30-50S juncture causing misreading and that's why it's cidal ^_^

That's all I got for now :)

Protein synthesis inhibitors labeled
Sorry for the bad image, we'll update it soon :)

I feel the only thing that can help you remember well is writing it (or singing it) like 50 times or mnemonics! They are fun and amazing if you remember em right.
Also I'm making a new label in the blog called "Mnemonics" :D
Have fun <3


This post is updated and continued here.


  1. MY REQUEST:- u shud work as professor and enlighten the future medicos!!

  2. Made me understand well.Thank you soo much.

  3. Love you IKaN....♡♡♡
    You're a saviour :)

  4. man you are just awesome�� keep up the good work .

  5. Really good post Ikan. Thank u so much, It helps me a lot.

  6. Finally I can keep these mechanisms of action in check... thank you so much.


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