Hey everyone!
We'll be learning about drugs that are used in Parkinson's disease.
Drugs and their mechanisms are hard to remember because they are soo many! I like pairing the action with the drug name to keep it simple!
Be selective about caps and combs.
Selegiline is a selective MAO-B inhibitor.
Entcapone and Tolcapone are COMT inhibitors.
Entcapone can't enter the CNS. Inhibits only peripheral COMT.
Tolcapone prevents L-dopa degradation in the brain as well as the periphery.
Pex got pin for the dopamine receptor.
Pramipexole, Rotigotine & Ropinirole are dopamine receptor agonists.
"Bro er.. Go to dopamine receptor"
Bromocriptine and Pergolide are ergot derivatives that act directly on the dopamine receptors.
Submitted by Nilima:
Tolcapone crosses BBB and is toxic to liver.
Tol = tall (can reach brain)
toL = L ( liver toxicity)
We'll be learning about drugs that are used in Parkinson's disease.
Drugs and their mechanisms are hard to remember because they are soo many! I like pairing the action with the drug name to keep it simple!
Be selective about caps and combs.
Selegiline is a selective MAO-B inhibitor.
Entcapone and Tolcapone are COMT inhibitors.
Entcapone can't enter the CNS. Inhibits only peripheral COMT.
Tolcapone prevents L-dopa degradation in the brain as well as the periphery.
Pex got pin for the dopamine receptor.
Pramipexole, Rotigotine & Ropinirole are dopamine receptor agonists.
"Bro er.. Go to dopamine receptor"
Bromocriptine and Pergolide are ergot derivatives that act directly on the dopamine receptors.
Submitted by Nilima:
Tolcapone crosses BBB and is toxic to liver.
Tol = tall (can reach brain)
toL = L ( liver toxicity)
That's all!
Pray for me < 3
-IkaN
simply MEDICOWESOME! thank you dude :D
ReplyDeleteHaha! You are most welcome dude =D
DeleteNice !! To remember ENTcapone as only a peripheral comt inhibitor, you can highlight the ENT in ENTcapone and think of it as ENTeric ( to emphasize the peripheral part ) hence enteric has to be in the periphery and can't go to the brain !
DeleteLove it!
DeleteThis is soooo helpful!!!THANK YOU SO SO MUCH!!:)
ReplyDeleteGlad it helped you!
DeleteMind blowing
ReplyDelete🤯
DeleteThank you so much bro
ReplyDelete