Saturday, August 9, 2014

Why are nonsteroidal anti-inflammatory agents avoided in myoardial infarction?

Good question!

Nonsteroidal anti-inflammatory agents, with the exception of aspirin, are avoided in the setting of myocaridal infarction.

It is because they can impair infarct healing and increase the risk of myocardial rupture, and their use may result in a larger infarct scar.

That's all!



  1. Replies
    1. The answer to your question goes back to Pathophysiology.

      Damage to many tissues leads to increased PGE2 synthesis via enhanced COX-2 expression. This contributes to inflammation and pain by vasodilation, increased vascular permeability and sensitisation of pain fibre nerve endings to the nociceptive action of bradykinin, serotonin and other mediators.

      However, in the later stages of repair following tissue damage, COX-2-derived prostanoids may contribute to the processes of wound healing.

      So if you are inhibiting COX by using NSAIDS or steroids, you are impairing wound healing!


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