Monday, December 29, 2014

Tissue plasminogen activator mnemonic

Greetings people!

Tissue plasminogen activator is an enzyme that catalyzes the conversion of plasminogen to plasmin, the enzyme responsible for clot breakdown.

It is used in the treatment of embolic or thrombotic stroke.
Contraindicated in hemorrhagic stroke and head trauma. The antidote for tPA in case of toxicity is epsilon aminocaproic acid.

Mnemonic is, "TPA"

T - Thrombotic and embolic stroke (Use)
P - Plasmin (Mechanism of action)
A - Aminocaproic acid (Antidote)

The dose mnemonic is, "TPA" again!

T for ten:
10% of dose given as bolus.

P mirrored looks like a 9:
0.9 mg/kg dose, maximum 90 mg.

A for an hour:
Rest of the dose is given as an infusion lasting for 60 minutes.

That's all!


  1. Plz post about INR..i alwys get confused with the topic about international normalised ratio..thanks ikan..


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