Wednesday, January 28, 2015

Apoptosis: Proapoptotic and anti-apoptotic molecules mnemonic

Hello! We are going to have life and death talks today.

Just kidding. We'll be talking about apoptosis - remembering molecules that promote or inhibit apoptosis, as the title suggests.

Let's start!

"Bax kills cells with an axe."
BAX promotes apoptosis.

"Caspase converts cells into casper (the ghost)."
Caspases promotes apoptosis. (Conversion into ghosts, that is, death).

"Dying is bad."
BAD promotes apoptosis.

Getting baked is like dying.
BAK promotes apoptosis.

I think bcl 2 is saying, "be clever, live" reminding us to live longer.
bcl 2 inhibits apoptosis and thus, is anti-apoptotic.

That's all!
Life and death.


  1. Apoptosis is inhibited by genes which ever can "c" the suicide :Bcl-2,Bcl-XL, Mcl-1 except bcal xs as it is extra small (xs) to stop them commit suicide. Which can see basically means which has letter c :)

  2. Replies
    1. Excellent observation. But I guess you meant to say, "except bcal-xs because it is extra small (xs), therefore too small to stop them (i.e., the apotosis genes)" Great observation. Thank you.


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