Thursday, January 29, 2015

Paracellular leak in the thick ascending limb

This fact had boggled me since first year physiology, finally got it figured out

Paracellular leak- sodium, potassium and chloride are absorbed into the cell by Na-2Cl-K transporter. But potassium is more permeable, hence it diffuses back into the luminal fluid. This creates positivity in the luminal fluid, which repels positive ions. Hence Mg, Ca, Na are pushed by the paracellular pathway to be absorbed.  

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