Sunday, September 20, 2015

Why is there an increased white cell count in sickle cell anemia?

Hello sweet people!
I spent today's free time searching for what is the cause of leukocytosis in sickle cell anemia =P

Sickle cell disease typography
There are multiple causes for leukocytosis in sickle cell disease. Here are a few reasons for the pathogenesis of increased WBC count in SCD -

1. Over stimulation of bone marrow for compensation of anemia:
Chronic medical conditions induce stimulation of the bone marrow as compensation for either anaemia or thrombocytopenia result in secondary leukocytosis. These conditions include haemolytic anaemias, such as sickle cell anaemia, in which leukocytosis is commonly found.

2. Altered RBC's are recognised and destroyed by white blood cells:
Sickle red cells also show a loss of phospholipid asymmetry with externalization of phosphatidylserine (PS), which is believed to play a significant role in promoting macrophage recognition with removal of erythrocytes (erythrophagocytosis).

3. Recurrent bacterial infections:
In sickle cell disease, there's an increased susceptibility to invasive bacterial infections because of dysfunctional antibody production, opsonophagocytosis, abnormalities of the alternate complement pathway, leukocyte functions, cell-mediated immunity and defective splenic clearance. Iron overload due to chronic blood transfusions is also a predisposing factor.

That's all!

Have a lovely day <3 


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