Tuesday, October 13, 2015

Study group discussion: Why are platelets low in hepatic disease?

Why are platelets low in hepatic disease?

You need cytokines to tell the marrow to synthesis platelets. They are synthesized chiefly by liver.

It is also been associated with the concept of hypersplenism leading to sequestration of thrombocytes in the enlarged spleen.

The cytokine thrombopoietin (TPO) is predominantly produced by the liver and constitutively expressed by hepatocytes. TPO production in humans is dependent on functional liver cell mass and is reduced when liver cell mass is severely damaged. This leads to reduced thrombopoiesis in the bone marrow and consequently to thrombocytopenia in the peripheral blood of patients with advanced-stage liver disease.

No comments:

Post a Comment

This is express yourself space. Where you type create something beautiful! <3
Wondering what do I write? Well...
Tell us something you know better. You are a brilliant mind. Yes, you are! ^__^
Ask about something you don't understand @_@?
Compliment... Say something nice! =D
Be a good critic and correct us if something went wrong :|
Go ahead. Comment all you like here! (:

PS: We have moderated comments to reduce spam. ALL comments that are not spam will be published on the website.