Monday, August 22, 2016

Antiphospholipid Syndrome mnemonic

Lemme tell you about APLA today :)

It is an autoantibody-mediated acquired thrombophilia characterized by recurrent arterial or venous
thrombosis and/or pregnancy morbidity.

The presence of at least one clinical and one laboratory criterion ensures the diagnosis:

Clinical criteria:
Vascular thrombosis defined as: One or more clinical episodes of 
- Arterial
- Venous
- Small vessel thrombosis
(In any tissue or organ.)
Pregnancy morbidity, defined as:
- One or more unexplained deaths of a morphologically normal fetus at or beyond the tenth week of gestation
- One or more premature births of a morphologically normal neonate before the thirty-fourth week
of gestation because of eclampsia, severe preeclampsia, or placental insufficiency
- Three or more unexplained consecutive spontaneous abortions before the tenth week of gestation.
Laboratory criteria:
- Lupus anticoagulant (LA)
- Anticardiolipin (aCL)
- Anti-β2GPI antibodies
(At intermediate or high titers on two occasions, 12 weeks apart.)

Antiphospholipid Syndrome mnemonic
That's all!

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