Hello!
So today I was reading about acyclovir and crystal induced acute kidney injury.
Acyclovir is rapidly excreted in the urine (being both filtered and secreted) and has a relatively low solubility. Intravenous (IV) therapy may lead to the deposition of acyclovir crystals in the tubules if the patient is volume depleted. This results in intratubular obstruction and foci of interstitial inflammation.
How do you prevent this? Fluids!
Which other drugs can do this?
Mnemonic! CRISTAL
Ciprofloxacin
R
Indinavir
Sulfonamides
T
Acyclovir
L
I couldn't fit methotrexate in the mnemonic though :/
Magadoses of vitamin C and ethylene glycol poisoning can also cause crystal induced AKI by precipitating oxalate crystals.
That's all!
And above all, watch with glittering eyes the whole world around you because the greatest secrets are always hidden in the most unlikely places. Those who don't believe in magic will never find it.
-IkaN
Related post: Envelop shape crystals - oxalate mnemonic
Hexagonal cyrstals - cystine mnemonic
So today I was reading about acyclovir and crystal induced acute kidney injury.
Acyclovir is rapidly excreted in the urine (being both filtered and secreted) and has a relatively low solubility. Intravenous (IV) therapy may lead to the deposition of acyclovir crystals in the tubules if the patient is volume depleted. This results in intratubular obstruction and foci of interstitial inflammation.
How do you prevent this? Fluids!
Which other drugs can do this?
Mnemonic! CRISTAL
 |
| Drugs causing crystal induced AKI mnemonic |
R
Indinavir
Sulfonamides
T
Acyclovir
L
I couldn't fit methotrexate in the mnemonic though :/
Magadoses of vitamin C and ethylene glycol poisoning can also cause crystal induced AKI by precipitating oxalate crystals.
That's all!
And above all, watch with glittering eyes the whole world around you because the greatest secrets are always hidden in the most unlikely places. Those who don't believe in magic will never find it.
-IkaN
Related post: Envelop shape crystals - oxalate mnemonic
Hexagonal cyrstals - cystine mnemonic
ME Pee CRISTAL
ReplyDeleteM-Methotrexate
E-Ethylene glycol
Pee-Protease inhibitor
C-Ciprofloxacin
R
I-Indinavir
S-sulfonamide
T-Triamterene
A-Acyclovir
L-lysis (Tumour Lysis syndrome- uric acid)