Saturday, August 20, 2016

Systemic sclerosis autoantibodies mnemonic

Today, I forgot which antibodies scleroderma is associated with T_T

Apparently, Qbanks don't write Scl-70 in their options. They like writing "Autoantibodies against topoisomearase I" and make my life difficult.

Anyway, here's my attempt to remember this next time. I don't know if it'll work. But hey, no harm trying?

Scleroderma, topoisomerase and centromere mnemonic
Here's a cool paragraph from Harrison:
Antinuclear autoantibodies are present in almost all patients with SSc and can be detected at disease onset. Autoantibodies against topoisomerase I (Scl-70) and centromere are mutually exclusive and quite specific for SSc. Topoisomerase I antibodies are detected in 31% of patients with dcSSc, but in only 13% of patients with lcSSc. They are associated with increased risk of ILD and poor outcomes. Anticentromere antibodies are detected in 38% of patients with lcSSc, but in only 2% of patients with dcSSc and rarely in patients with Raynaud’s phenomenon and Sj√∂gren’s syndrome. Anticentromere antibodies in SSc are associated with PAH, but only infrequently with significant cardiac or renal involvement or ILD.

That's all!
Happy 20th August, everyone!


This is express yourself space. Where you type create something beautiful! <3
Wondering what do I write? Well...
Tell us something you know better. You are a brilliant mind. Yes, you are! ^__^
Ask about something you don't understand @_@?
Compliment... Say something nice! =D
Be a good critic and correct us if something went wrong :|
Go ahead. Comment all you like here! (:

PS: We have moderated comments to reduce spam. ALL comments that are not spam will be published on the website.