Saturday, October 29, 2016

Step 2 CK: Treatment of narcolepsy and cataplexy

Treatment of Narcolepsy:
Patients with sleepiness severe enough to require medication can be treated with stimulant medications.

Modafinil - First line pharmacologic therapy for narcolepsy.
Well tolerated.
Illicit use is rare.
MOA: Increases dopaminergic signaling.
Methylphenidate, or amphetamines may be used. Not preferred due to cardiovascular and psychiatric side effects.

REM sleep-suppressing medication (eg, venlafaxine, fluoxetine, atomoxetine) - First line therapy for cataplexy.

For patients whose sleepiness or cataplexy does not improve with one of these medications, sodium oxybate may be of benefit.

Source: Uptodate
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