Friday, March 31, 2017

Trastuzumab notes + mnemonic

Trastuzumab (Herceptin) is a humanized monoclonal antibody directed against the extracellular domain of the tyrosine kinase receptor HER2.

It is used in HER2-overexpressing breast cancers.

It is associated with a risk for cardiotoxicity

Trastuzumab-induced cardiotoxicity presents with a range of severity from asymptomatic decline in left ventricular ejection fraction (LVEF) to symptomatic heart failure.

Monitoring of LVEF (by echocardiogram or multigated acquisition scan) at baseline/pretreatment and at 3–4-month intervals throughout trastuzumab treatment, in combination with clinical evaluation for symptoms of heart failure is standard practice.

Mnemonic: Trust (Trastuzumab) her to (HER2) steal your heart (Cardiotoxic) with her breasts (Used in breast cancer).

Another memory aid: HERceptin affects HEaRt.

That's all!


  1. i attended a conference on her2 ... the use of transtuzamab is still being considered and has not been introduced in our country Pakistan atleast.In addition to its sideeffects its an expensive drug


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