Trastuzumab (Herceptin) is a humanized monoclonal antibody directed against the extracellular domain of the tyrosine kinase receptor HER2.
It is used in HER2-overexpressing breast cancers.
It is associated with a risk for cardiotoxicity
Trastuzumab-induced cardiotoxicity presents with a range of severity from asymptomatic decline in left ventricular ejection fraction (LVEF) to symptomatic heart failure.
Monitoring of LVEF (by echocardiogram or multigated acquisition scan) at baseline/pretreatment and at 3–4-month intervals throughout trastuzumab treatment, in combination with clinical evaluation for symptoms of heart failure is standard practice.
Mnemonic: Trust (Trastuzumab) her to (HER2) steal your heart (Cardiotoxic) with her breasts (Used in breast cancer).
Another memory aid: HERceptin affects HEaRt.
That's all!
-IkaN
It is used in HER2-overexpressing breast cancers.
It is associated with a risk for cardiotoxicity
Trastuzumab-induced cardiotoxicity presents with a range of severity from asymptomatic decline in left ventricular ejection fraction (LVEF) to symptomatic heart failure.
Monitoring of LVEF (by echocardiogram or multigated acquisition scan) at baseline/pretreatment and at 3–4-month intervals throughout trastuzumab treatment, in combination with clinical evaluation for symptoms of heart failure is standard practice.
Mnemonic: Trust (Trastuzumab) her to (HER2) steal your heart (Cardiotoxic) with her breasts (Used in breast cancer).
Another memory aid: HERceptin affects HEaRt.
That's all!
-IkaN
i attended a conference on her2 ... the use of transtuzamab is still being considered and has not been introduced in our country Pakistan atleast.In addition to its sideeffects its an expensive drug
ReplyDeleteYup!
Delete