Thursday, May 11, 2017

Fact of the day: Psychiatric effects of steroids

Did you know corticosteroid therapy can cause depression, mania, psychosis, and delirium?


The mechanism by which the corticosteroid induces symptoms such as mania, depression, and psychosis is not clear.

The administration of prednisone is associated with decreased levels of corticotrophin, norepinephrine, and beta-endorphin in the cerebrospinal fluid. Furthermore, corticosteroids induce an increased release of glutamate that induces neuronal toxicity due to accumulation effect.



  1. The title is misleading. 😇

    1. That's what the research paper said!

      I'll change it though. Psychic effects of steroids sounds too cool.


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