Thursday, June 8, 2017

Neuroblastoma mnemonic


The term neuroblastoma is commonly used to refer to a spectrum of neuroblastic tumors (including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas) that arise from primitive sympathetic ganglion cells and, like paragangliomas and pheochromocytomas, have the capacity to synthesize and secrete catecholamines.

Remember the N myc mnemonic for neuroblastoma :

N - Neuroblastoma, N myc gene
M - Crosses midline (differentiates from Wilms)
MY - MYoclonus (Opoclonus myoclonus)
C - Calcifications in tumor present
C - Catecholamine secretion

You can also remember "High BP" for additional findings seen in neuroblastoma:

Horner syndrome
Heterochromia iridis (different colors of the iris or portions of the iris)
Homovanillic acid and vanillylmandelic acid elevated in urine
Bombesin positive
Back pain
Bone pain
Beckwith-wiedemann syndrome association
Posterior mediastinum or retroPeritoneal mass
Purple skin lesions
Periorbital ecchymoses

That's all!


  1. Also add H for hutchin syndrome ie irritability n tenderness in child due to bony mets
    P for pepper syndrome ie adrnl neuroblastoma with massive liver mets.

  2. Wilma tumour (not neuroblastoma) is associated with Beckwith-Wiedemann syndrome.


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