Friday, June 30, 2017

Response of Vagus to Systemic Injury.


Let's learn/revise.

The vagus nerve exerts several homeostatic influences, including enhancing gut motility, reducing heart rate, and regulating inflammation.

Central to this pathway is the understanding of neurally controlled anti-inflammatory pathways of the vagus nerve.

This neurally mediated anti-inflammatory pathway allows for a rapid response to inflammatory stimuli and also for the potential regulation of early proinflammatory mediator release, specifically tumor necrosis factor (TNF).

Vagus nerve activity in the presence of systemic inflammation may inhibit cytokine activity and reduce injury from disease processes such as pancreatitis, ischemia and reperfusion, and hemorrhagic shock.
This activity is primarily mediated through nicotinic acetylcholine receptors on immune mediator cells such as tissue macrophages.

Furthermore, enhanced inflammatory profiles are observed after vagotomy, during stress conditions. 

Let's learn Together!

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