Sunday, August 20, 2017

Medicollabowesome: CD4 and Cavitatory lesions in HIV

What is Medicollabowesome? How can I collaborate?
HIV patients are prone to a whole spectrum of opportunistic infections with decreasing CD4 count and one of the commonest is Tuberculosis.

Normally, primary tuberculosis does not show cavitatory lesions while secondary tb does- higher grade of immune activation in secondary tb causes parenchymal damage leading to cavitation.

Now, the scenario is HIV patients is very unique. With decreasing CD4 counts, they would be more prone to tb and rather, disseminated form of tb but they simply don't have immune cells! So, the risk of cavitatory tb lowers with decreasing CD4 counts. The problem- the patient may not present early as he or she may not have a productive sputum.

Pranav Patwardhan

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