The current CDC classification system for HIV-infected adolescents and adults categorizes persons on the basis of clinical conditions associated with HIV-infection and CD4+ T lymphocytes counts which is represented by a matrix of nine mutually exclusive categories.
Classification system for HIV-infection:
Category A- Asymptomatic, acute HIV or progressive generalized lymphadenopathy
A1 - >500/muL
A2 - 200-499/muL
A3 - <200/muL
Category B- Symptomatic
B1 - >500/muL
B2 - 200-499/muL
B3 - <200/muL
Category C- AIDS indicator conditions
C1 ->500/muL
C2 -200-499/muL
C3 -<200/muL
Clinical manifestations belonging to each category:
Category A- One or more conditions with documented HIV infection and category B and C conditions must not have occured
- Asymptomatic HIV infection
- Progressive generalized lymphadenopathy
Category B- Symptomatic conditions that are not included under category C and meets the following criteria, (a) infection is indicative of defect in cell mediated immunity; (b) clinical course and management is complicated by HIV infection.
- Bacillary angiomatosis
- Candidiasis- thrush, vulvovaginal
- Cervical dysplasia/ cervical carcinoma in situ
- Fever or diarrhea lasting >1 month
- Hairy leukoplakia
- Shingles, atleast two distinct episodes or more than one dermatome
- ITP
- PID
- Peripheral neuropathy
- Listeriosis
Category C- Conditions listed in AIDS surveillance case definition
- Candidiasis of bronchi, trachea, lungs, oesophagus
- Cervical carcinoma invasive
- Coccidiodomycosis, disseminated or extrapulmonary
- Cryptococcosis, extrapulomary
- Cryptosporidiosis, >1 month's duration
- CMV, other than liver, spleen, nodes
- CMV retinitis with loss of vision
- Encephalopathy
- HSV, ulcers lasting >1 month's duration
- Histoplasmosis, disseminated or extrapulmonary
- Isosporiasis, chronic intestinal >1 month
- Kaposi sarcoma
- Burkitt's lymphoma
- Lymphoma of brain
- MAC
- MTB
- Pneumocystis jiroveci pneumonia
- Recurrent pneumonia
- Progressive multifocal leucoencephalopathy
- Salmonella septicemia, recurrent
- Toxoplasmosis of brain
- Wasting syndrome due to HIV
Shivani Mangalgi
Medicowesome 2017
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