Vasopressin (arginine-vasopressin) Pitressin, Vasostrict
0.03 units per minute (alternatively 0.01 to 0.03 units/minute initially) 0.03 to 0.04 units per minute (not titrated)
0.04 to 0.07 units/minute;
Doses >0.04 units/minute can cause cardiac ischemia and should be reserved for salvage therapy
Add-on to norepinephrine to raise blood pressure to target MAP or decrease norepinephrine requirement. Not recommended as a replacement for a first-line vasopressor.
Pure vasoconstrictor; may decrease stroke volume and cardiac output in myocardial dysfunction or precipitate ischemia in coronary artery disease.
Must be diluted; eg, a usual concentration is 25 units in 250 mL D5W or NS (0.1 units/mL)
Bhopalwala. H
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