Thursday, April 18, 2019

Chimeric antigen receptor T cells (CAR T cells) therapy simplified

Hey everyone! Upasana - our funny medical student made a simplified video on CAR T cell therapy. Check it out!



I copy-pasted a quick short post in text for reference :)



What are CAR T cells?
Chimeric antigen receptor T cells are T cells that have been genetically engineered to produce an artificial T-cell receptor.

What is CAR T cell therapy?
The premise of CAR-T immunotherapy is to modify T cells to recognize cancer cells in order to more effectively target and destroy them.

How?
T cells are purified and then transduced with a gene encoding the engineered CAR via a retroviral vector, typically either an integrating gammaretrovirus (RV) or a lentiviral (LV) vector.

Whose T cells are used?
T cells are used from either the patient's own blood, known as an autologous treatment, or from the blood of a healthy donor, known as an allogenic treatment.

CAR T cell therapy is used for?
Early CAR-T cell research has focused on blood cancers. The first approved treatments use CARs that target the antigen CD19, present in B-cell-derived cancers such as acute lymphoblastic leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL). There are also efforts underway to engineer CARs targeting many other blood cancer antigens, including CD30 in refractory Hodgkin's lymphoma; CD33, CD123, and FLT3 in acute myeloid leukemia (AML); and BCMA in multiple myeloma.
Source: Wikipedia

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