Friday, July 26, 2019

Fas- fas ligand interactions and uveitis

-Fas ligand/ FasL/ CD95 ligand is a type 2 membrane protein belonging to the TNF superfamily and is found on lymphocytes.

-In the eye, it is expressed on Iris and corneal endothelial cells.

-In the rest of the body, it is expressed on the thymus, testes, and the brain.

-Liver and intestines express this only in periods of severe inflammatory process.

- Apoptosis of the T lymphocytes can be triggered by FasL. Loss of this mechanism is touted to be one of the causes of uveitis.

Mechanism by which it acts is believed to be the selective apoptosis of cells producing TNF or by IL2 activation of lymphocytes.

-Sushrut

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