Tuesday, August 6, 2019

Definition of generalized convulsive status epilepticus

Hi everyone,

Historically, the International League Against Epilepsy (ILAE) and others defined status epilepticus as a single epileptic seizure of >30 minutes duration or a series of epileptic seizures during which function is not regained between ictal events in a 30-minute period.

However, a 30-minute definition is neither practical nor appropriate in clinical practice.


An accepted operational definition:
≥5 minutes of continuous seizures, or
≥2 discrete seizures between which there is incomplete recovery of consciousness

In 2015, the ILAE published a revised conceptual definition of status epilepticus that incorporates two operational dimensions, t1 and t2:
Status epilepticus is a condition resulting from either the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms that lead to abnormally prolonged seizures (after time point t1).
Status epilepticus is a condition that can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures.

Just FYI

-IkaN

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