Saturday, October 26, 2019

Denosumab

Hi! Long time no see :)

This post is on Denosumab!

MOA:
- Monoclonal antibody against the receptor activator of nuclear factor κB ligand (RANKL)
- Reduces bone resorption by inhibiting the development of osteoclasts

Route: SC
Dosing: Administered twice yearly



Adverse effects:
- Hypocalcemia if vitamin D deficient
- Increased rate of cellulitis and bronchitis
- Osteonecrosis of the jaw
- Atypical femur fracture

Notes:
- Expensive
- Should be continued indefinitely (discontinuation results in loss of BMD and has been associated with an increased risk of vertebral fracture)
- Safely in CKD (KDIGO stage G3b and G4)
- Preferred if poor adherence or tolerance of oral bisphosphonates

- IkaN

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