Saturday, November 23, 2019

Cryoprecipitate

Hey! =)

What does cryoprecipitate contain? 
Cryoprecipitate preparations contain concentrated amounts of fibrinogen (factor I), factor VIII (antihaemophilic factor), von Willebrand factor, factor XIII (fibrin-stabilizing factor), and fibronectin.

Why is it called cryoprecipitate?

It has to do with how it is made :D
cryo: involving or producing cold, especially extreme cold.
precipitate: cause (a substance) to be deposited in solid form from a solution.

Cryoprecipitate is generated by thawing fresh frozen plasma at 1-6 degrees C (33.8-42.8 degrees F) and recovering the cold insoluble precipitate by centrifugation. Precipitates are resuspended in small volume of residual plasma (5-20 mL) and stored at -18 to -25 degrees C (-0.4 to -13 degrees F).

What constitutes a single unit of cryoprecipitate? 
Single units are typically pooled into 5-unit pools before or after freezing.

What is the dosing?
In adults, common dosing is 2 pools of cryoprecipitate (5 units of cryoprecipitate/pool) which is expected to increase fibrinogen levels by 100 mg/dL (1 g/L) depending on the indication.

-IkaN


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