Medicowesome urges you to take the SARS-CoV-2 virus seriously and to stay safe during the COVID-19 pandemic.



Tuesday, January 14, 2020

Ocular Alzheimer's disease

A paper published in 2003 has dubbed glaucoma as 'ocular Alzheimer's disease' because some of the pathophysiological elements are similar.


1. Neuronal apoptosis involves caspase activation in both diseases.

2. Caspase activation causes the up-regulation of amyloid-beta production due to the cleavage of the amyloid precursor protein. 

3. Age-related mitochondrial dysfunction plays a role in both diseases.

4. Glutamate elevation and nitric oxide synthase upregulation have been implicated in the neurotoxicity of the both. 

5. In the synaptic dysfunction, glutamate toxicity is involved, common to glaucoma and Alzheimer's.


-Sushrut 

No comments:

Post a Comment

This is express yourself space. Where you type create something beautiful! <3
Wondering what do I write? Well...
Tell us something you know better. You are a brilliant mind. Yes, you are! ^__^
Ask about something you don't understand @_@?
Compliment... Say something nice! =D
Be a good critic and correct us if something went wrong :|
Go ahead. Comment all you like here! (: