Tuesday, January 14, 2020

Ocular Alzheimer's disease

A paper published in 2003 has dubbed glaucoma as 'ocular Alzheimer's disease' because some of the pathophysiological elements are similar.

1. Neuronal apoptosis involves caspase activation in both the diseases.

2. Caspase activation causes up regulation of amyloid beta production due to the cleavage of amyloid precursor protein. 

3. Age related mitochondrial dysfunction plays a role in both the diseases.

4. Glutamate elevation, and nitric oxide synthase up regulation has been implicated in the neurotoxicity of the both. 

5. In the synaptic dysfunction, glutamate toxicity is involved, common to glaucoma and Alzheimer's.


-Sushrut 

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