Tuesday, January 14, 2020

Ocular Alzheimer's disease

A paper published in 2003 has dubbed glaucoma as 'ocular Alzheimer's disease' because some of the pathophysiological elements are similar.

1. Neuronal apoptosis involves caspase activation in both diseases.

2. Caspase activation causes the up-regulation of amyloid-beta production due to the cleavage of the amyloid precursor protein. 

3. Age-related mitochondrial dysfunction plays a role in both diseases.

4. Glutamate elevation and nitric oxide synthase upregulation have been implicated in the neurotoxicity of the both. 

5. In the synaptic dysfunction, glutamate toxicity is involved, common to glaucoma and Alzheimer's.


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