Tuesday, March 31, 2020

Rickettsia mnemonic

Hi!

Do you want to learn about Rickettsia today?

Rickettsia mnemonic (Rickettsia typhi, flea vector)

Rickettsia: Genus of nonmotile, Gram-negative, highly pleomorphic bacteria (cocci, bacilli, coccobacilli, or threads).

Rickettsia rickettsii
Causes: Rocky Mountain spotted fever
Hosts/Transmitted via: Ixodes ticks

Rickettsia typhi
Causes: Murine typhus.
Hosts/Transmitted via: Fleas

Pathological lesion: Vasculitis
Pathogenesis: Mediated by the direct action of the organism on the vessel wall causing vascular denudation and endothelial injury. [1]

Fun fact: Rickettsia can synthesize adenosine triphosphate (ATP) but they are also energy parasites. They transport ATP from the host cell cytoplasm using the ATP/ADP translocase. [2]

Mnemonic: Imagine the Ricket riding an arthropod, saying that we must go to ATP house (cell), and injuring the endothelium on its way.

PS: I also drew the Ixodes tick.

Rickettsia rickettsii, Ixodes ticks
The previous post on Rickettsia no longer has the image we originally uploaded. I could not retrieve it. But here is the good thing about imagination and art, you can always recreate lost work.

-IkaN

References:
[1] Silverman DJ. Rickettsia rickettsii-induced cellular injury of human vascular endothelium in vitro. Infect Immun. 1984 Jun;44(3):545-53.

[2] Schmitz-Esser S, et al. ATP/ADP translocases: a common feature of obligate intracellular amoebal symbionts related to Chlamydiae and Rickettsiae. J Bacteriol. 2004;186(3):683–691.

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