Hello
In case of granulomatous diseases, macrophages activated by Th1 cells lead to increased levels of TNF-alpha. Now, TNF-alpha induces and maintains granuloma formation. Basic, right?
So we give anti-TNF drugs (adalimumab, infliximab, etc.). However, they cause the granuloma to break down, thus leading to disseminated disease.
Bottom line - Always remember to check for the presence of latent TB before starting anti-TNF therapy.
That's all
- Jaskunwar Singh
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