Friday, January 22, 2021

Why von Willebrand disease has normal aPTT sometimes ?

VWF acts as a carrier protein for factor VIII.  Factor VIII is more rapidly degraded when unbound, and VWF deficiency can therefore lead to impairment of the intrinsic coagulation pathway leading to a prolonged activated PTT.  

However, patients can have a normal aPTT for a variety of reasons:

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