Monday, June 13, 2016

Oral hypoglycemic drugs used for diabetes mellitus mnemonic

Hello!

So whenever there is a LOT of things to remember, like a lot of drug classes or a lot of microorganisms, I personify them. I make them real life characters and give them creep personality traits.

Here's a mnemonic kinda thingy on drugs used in diabetes mellitus aka oral hypoglycemics!
Biguanides: Inhibits hepatic glucogenesis and increases peripheral uptake of glucose.

Metformin meets glucose and advises it to stay out of the blood. It asks the liver to keep glucose in the house (Inhibits hepatic glucose production) and asks the glucose in the bloodstream to go into adipose and skeletal muscle (Stimulates peripheral uptake of glucose). Metformin never met a glucose molecule and did not tell him to not stay in blood :P

Metformin mnemonic
Sulfonylureas: Mimic action of glucose by closing K+ channels in pancreatic β cells, which leads to depolarization and increased Ca2+ influx,  releasing insulin.

Sulfonylureas summon insulin. They close the potassium gates in the haunted graveyard of the pancreas and chant depolarizing spells that open calcium channel. This brings back insulin from the dead. GlyBuride is more like Ghost Bringer.

Sulfonylureas mnemonic
Drugs ending with -gliptins (Sitagliptin, etc) are dipeptidyl peptidase 4 (DPP-4) inhibitors. They act to inhibit degradation of the endogenous incretins GLP-1 and GIP.
Mnemonic: GLIP!

DPP4 inhibitors mnemonic
α-glucosidase inhibitors:
Acarbose - Alpha glucosidase inhibitor. Aaaaa!

Amylin mimetics:
Amylin rhymes with insulin to remember that amylin mimetics like pramlintide increase secretion of insulin and delay gastric emptying.

Glitazones (thiazolidinediones) mnemonic:
Pioglitazone - PI
Peroxisome proliferator-activated receptors (PPARs)
Improves insulin sensitivity

Also, remember that thiazolidinedione derivatives
THiazoLidinedione: Toxic to Heart and Liver

That's all!
Mnemonic made for my favorite senior, Manasi < 3
-IkaN

Related posts:
Bromocriptine in diabetes
Can excessive use of antibiotics in children cause diabetes?
ACE inhibitors in diabetic nephropathy

12 comments:

  1. Hey ikan,
    thanx for that 😊😊😊

    ReplyDelete
    Replies
    1. Very nice. Both telling simple stories, with accompanying pictures creates anchors and connections which makes recall more spontaneous.

      Delete
    2. Thank you so much for the compliments!

      Delete
  2. Have you stopped adding people to study groups?

    ReplyDelete
    Replies
    1. No, we are still adding people.

      Can you write us another email... Maybe we didn't recieve your email :/

      Delete
  3. Thank you! This is so cute! ^_^

    ReplyDelete

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