Do you know? Cocaine addiction leads to increased concentration of iron in globus pallidus. The more one takes this drug, more amounts of iron get accumulated in this region of brain, which normally acts as a 'brake' for inhibiting behaviour.
Also, the increased concentration of iron in brain is accompanied by iron deficiency in rest of the body.
This is possibly attained by decreasing absorption of iron from food and increasing permeability of blood- brain barrier.
- Jaskunwar Singh