Thursday, February 2, 2017

Why do infants of diabetic mothers develop polycythemia?

Why do infants of diabetic mothers develop polycythemia?

It's due to hyperinsulinemia!
Chronic fetal hyperinsulinemia results in elevated metabolic rates that lead to increased oxygen consumption and fetal hypoxemia, as the placenta may be unable to meet the increased metabolic demands. Fetal hypoxemia contributes to increased erythropoiesis.

Hyperinsulinemia also causes an increase in fetal size. This again results in hypoxemia, causing an increased synthesis of erythropoietin leading to polycythemia (The Pedersen hypothesis).

Thanks, study group 5, for helping me resolve this doubt! :)

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