Hi everyone. Here's a short post highlighting drugs causing edema.
Remember : SWOLLEN
S - Steroids
W (V) - Vasodilator drugs
O - Oral Hypoglycemic drug - Glitazones
L - CycLosporine
E - Endocrine - Growth Hormone
N - NSAIDs
1. Steroids -
Due to the Mineralocorticoid action of reabsorbing the Sodium from the kidneys, they act as volume expanders.
2. Vasodilator drugs -
Especially CCB's like Amlodipine are known to cause this. Other Vasodilator drugs used for hypertension can also cause edema like Alpha Methyl dopa, Hydralazine, etc
3. Oral Hypoglycemic drug : Glitazones -
The Glitazones act on the PPAR gamma receptors. These receptors are also present in the kidneys and vascular system. They somehow modulate the kidneys to reabsorb Na+ and also act on the level of blood vessels via PPAR receptors.
This is one of the reasons why they are c/i in Heart failure and Liver cirrhosis ( as they cause fluid overload).
4. Cyclosporine -
Reduces the GFR , thus more fluid retention.
5. Growth hormone. I don't understand why. Do tell me if you find out !
6. NSAIDs -
NSAIDs inhibit PG synthesis in kidneys causing renal vasoconstriction and this reducing the GFR.
This causes excess fluid accumulation eventually causing edema.
Happy studying. Stay awesome. :)