Seizures often occurs in ethylene glycol poisoning. It has multifaceted pathophysiology but one of the major cause is hypocalcemia.
Hypocalcemia occurs in ethylene glycol poisoning because ethylene glycol is metabolized to oxalate, which forms calcium oxalate depleting calcium from ECF.
Also, correcting associated metabolic acidosis by bicarbonate supplementation can further cause hypocalcemia due to increased binding of calcium to albumin.
This is why, calcium levels should always be monitored meticulously in such patients.
- Kirtan Patolia ( BJ medical college)
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